Table 3.

Calcineurin and cyclophilin A mutations confer resistance to CsA and CsA analogsa

StrainGenotypeCsA209–825211–810
30°C37°C30°C37°C30°C37°C
MICMFCMICMFCMICMFCMICMFCMICMFCMICMFC
H99CNA1 CPA1 CPA212.5>1000.390.78>1000.781.56>1001.5625
PW26CPA1 cpa1::ADE2>10050>100>10050>100>1001.56>50
PW47cpa1 cpa2>100>100>100>100>100>100
PW48cpa1 cpa2>100>100>100>100>100>100
MCC11CNA1-1>100>100>100>100>100>100
MCC12CNA1-2>100>100>100>100>100>100
  • a All MICs and MFCs given in micrograms per milliliter. –, not determined.