Table 2.

Antifungal activities of SCH and FLC against C. albicans 3474 and C. neoformans 486 at multiples of MICsa

DrughLog variation of CFU/ml for the indicated isolate at the indicated multiple of MICb
C. albicansCryptococcus neoformans
0.250.51248160.250.5124816
FLC6−0.07−0.17−0.11−0.26−0.33−0.74−0.82−0.05−0.05−0.15−0.15−0.15−0.15−0.15
SCH 56592−0.16−0.16−0.12−0.48−0.40−0.49−0.54−0.10−0.10−0.09−0.09−0.09−0.10−0.08
FLC120.00+0.010.00+0.01−0.98−1.35−1.41−0.09−0.31−0.55−0.73−0.83−0.84−0.89
SCH 56592−0.14−0.47−0.46−0.92−0.99−0.98−1.06−0.19−0.59−0.64−0.75−0.77−0.77−0.80
FLC24+0.02−0.03−0.02+0.02−0.93−0.88−0.820.00−0.12−0.71−1.66−1.85−1.87−1.91
SCH 56592−0.13−0.55−0.54−0.67−0.71−0.74−0.68−0.30−1.47−2.10−2.31−2.31−2.37−2.44
FLC480.00−0.01−0.01−0.04−0.07−0.61−0.610.00−0.07−0.13−2.12−2.36−2.44−2.44
SCH 56592−0.08−0.30−0.61−0.66−0.63−0.63−0.690.00−0.67−2.08−2.42−2.62−2.77−2.77
FLC72NDcNDNDNDNDNDND−0.04−0.08−0.09−1.22−2.10−2.14−2.26
SCH 56592NDNDNDNDNDNDND0.00−0.39−1.65−2.34−3.20−3.21−3.25
  • a The antifungal activity is expressed as the logarithmic variation of the ratio of CFU of treated cells per milliliter to CFU of untreated cells per milliliter for each time point considered.

  • b FLC MICs were 0.25 and 4.0 μg/ml and SCH 56592 MICs were 0.06 and 0.25 μg/ml for C. albicans andC. neoformans, respectively.

  • c ND, not determined.