Table 2.

Effect of sorbitol on susceptibility of C. albicans MY1055 to acidic terpenoids

CompoundAntifungal activity (μg/ml)a
Medium aloneMedium with sorbitol
Amphotericin B0.30.3
Digitonin2.52.5
L-7335600.08>5.0
Enfumafungin0.04>5.0
Ascosteroside0.2>20.0
Ergokonin A0.6>20.0
Arundifungin5.050.0
  • a The MICs were determined in CM or CMS as outlined in the Materials and Methods. The results for all compounds except ascosteroside are MICs. The results for ascosteroside are not the concentration of compound required to inhibit growth by 100% (MIC) but, rather, are the lowest concentration required to reduce the growth of Candida by 50% compared to the growth of untreated cells.