Table 5.

Effect of fks1-2 mutation in S. cerevisiae on sensitivities of cells and glucan synthase to L-733560, papulacandin, and acidic terpenoidsa

CompoundMY2141 (FKS1 FKS2)MY2140 (fks1-2 FKS2)
MIC (μg/ml)IC50 (μg/ml) for GSMIC (μg/ml)IC50 (μg/ml) for GS
L-7335600.310.425.025.0
Papulacandin5.03.025.050.0
Enfumafungin0.163.02.5>50.0
Ascosteroside10.010.0>100.0>100.0
Ergokonin A5.04.050.030.0
Arundifungin5.04.020.0>25.0
  • a MICs were determined as described in Materials and Methods, and glucan synthase (GS) assays were performed using the Brij 35 conditions.