Table 3.

Prolonged survival of mice systemically infected withA. fumigatus after treatment with CMA, FLC, or a combination of botha

GroupCMAFLC (mg/kg)MSDNo. of survivors/no. of treated micePbversus:
Group 1Groups 3, 4, and 5
107.00/5
2+0>20.62/50.0082
33.18.40/50.4354
412.511.60/50.0434
550>20.21/50.0086
6+3.1>25.63/50.00780.0098
7+12.5>28.04/50.00680.0094
8+50>30.05/50.00520.0188
  • a Mice that received three weekly immunizations with CMA (+) or saline (−) emulsified in CFA first and IFA thereafter were infected by A. fumigatus 7 days after the last immunization. Thereafter, they received FLC (3.1, 12.5, or 50 mg/kg once daily) for 4 consecutive days or saline (0 mg/kg) as a control. Survival was observed for 30 days after infection. Data are representative of two individual experiments.

  • b Generalized Wilcoxon test versus control (group 1) or the respective group treated with FLC (groups 3, 4, or 5). There were no significant differences between the CMA immunization only group (group 2) and the groups given CMA combined with FLC (groups 6, 7, or 8).