Table 3.

Correlation of quinolone MIC and mutation in quinolone-resistant pneumococcal strains

StrainMIC (μg/ml) of:Mutation(s) in:
GemifloxacinCiprofloxacinLevofloxacinSparfloxacinGrepafloxacinTrovafloxacinParCParEGyrAGyrB
10.03168442S79-F, K137-NI460-VS81-FNone
20.06840.50.50.25S79-YI460-VNoneNone
30.068410.50.25D83-NI460-VS81-FNone
40.0684110.25S79-F, K137-NI460-VS81-FNone
50.12588110.25R95-CD435-NS81-FNone
60.12588822S79-Y, K137-NI460-VE85-KNone
70.12588110.5NoneI460-VNoneNone
80.12588110.5S79-YNoneNoneNone
90.12588211S79-YNoneNoneNone
100.12588421S79-FI460-VS81-CNone
110.12588441S79-FI460-VS81-FNone
120.125>3216141S79-FI460-VNoneD435-N
130.25168821S79-F, K137-NI460-VNoneE474-K
140.251616841S79-F, K137-NI460-VS81-FNone
150.251616841S79-F, K137-NI460-VS81-FNone
160.251616842S79-FI460-VS81-FNone
170.251616842D83-NNoneS81-FNone
180.251616842S79-FI460-VS81-FNone
190.251616842S79-FI460-VS81-FNone
200.253216842S79-F, K137-NI460-VE85-KNone
210.253216841S79-F, K137-NI460-VS81-FNone
220.253216842S79-FI460-VS81-YNone
230.253216882S79-YNoneS81-ANone
240.532321684S79-F, K137-NI460-VS81-FNone
250.532321684D83-G, N91-DNoneS81-FNone
260.5>32>32>3284S79-FNoneS81-YNone
271>32>32>32168S79-YI460-VS81-FNone
281>32>32>32168D83-G, N91-DNoneS81-F, S114-GNone