Table 1.

Antifungal activity of immunization with CMA against systemic infections by C. albicansor A. fumigatusa

AntigenC. albicansA. fumigatus
MSDNo. of survivors/no. treated (P)bMSDNo. of survivors/no. treated (P)b
Saline8.60/55.30/6
CMA × 2>30.05/5 (0.0052)>18.82/6 (0.0048)
Live cells × 2>27.17/9 (0.0014)NT
Saline14.00/87.20/5
CMA × 3>30.07/7 (<0.001)>20.62/5 (0.0068)
  • a Mice received two (× 2) or three (× 3) weekly immunizations with CFA or IFA as described in Materials and Methods. Mice were infected with C. albicans (2.5 × 105 cells/mouse) 7 days after the last immunization. Survival was observed for 30 days after infection. NT, not tested.

  • b Generalized Wilcoxon test versus control group injected with saline.