Table 4.

Effect of assay conditions on potencies of L-733560 and acidic terpenoids in glucan synthase assay of C. albicans MY1055

CompoundGlucan synthase IC50 (μg/ml)Concn (μg/ml) required to inhibit whole-cell glucan synthesis to 50% of that for the control
Standard assayModified assay
L-7335600.0010.0020.04
Enfumafungin1–>251.00.05
Ascosteroside>25.07.00.05
Ergokonin A3.00.2
Arundifungin10.06.06.25
  • a Glucan synthase assays were performed as outlined in Materials and Methods.