Table 2.

Effects of mammalian MDR modulators on susceptibility ofA. fumigatus to aureobasidin A

CompoundConcnMIC of aureobasidin A (μg/ml)
None>50
Chlorpromazinea 0.025 mM1.6
Trifluoperazinea 0.010 mM1.6
Verapamil0.2 mM3
Nifedipine0.2 mM>50
Cyclosporin A0.2 mM>50
Quinidine0.2 mM>50
Reserpine0.2 mM>50
Forskolin0.2 mM>50
Triton X-1001.0%>50
Tween 201.0%>50
  • a Displayed antifungal activity at 0.2 mM.