Table 3.

Efficacy of continuous FK463 infusion in mouse models of pulmonary aspergillosis

Concn of FK463 (mg/ml) injected into pumpPlasma FK463 concna(μg/ml)Viable count (log CFU/lung)b
Control3.99 (0.39)
0.50.233.71 (0.48)
10.552.82 (0.48)*
20.912.14 (0.79)**
41.551.71 (0.64)**
  • a The lower limit of quantification of each compound was 0.05 μg/ml.

  • b Numbers in parentheses represent standard deviations. ∗, P < 0.05 (comparison with control); ∗∗, P < 0.01 (comparison with control).