Table 1.

Mean pharmacokinetic parameters of SCH 56592 in mice, rats, dogs, and cynomolgus monkeysa

Species (n)Parameteri.v. in HPβCDp.o. in HPβCDp.o. in MC
Mouse (3)Cmax(μg/ml)7.8 (13)6.3 (11)
Tmax (h)2.0 1.0 
AUC0–∞(μg · h/ml)137.0143.0 63.7 
t1/2 (h)7.0
Bioavailability (%)104.0 46.5 
Rat (3)Cmax(μg/ml)3.5 (13)3.0 (20)
Tmax (h)2.0 4.0 
AUC0–∞(μg · h/ml)89.458.6 43.0 
t1/2 (h)7.0
Bioavailability (%)65.6 48.0 
Dog (2)Cmax (μg/ml)3.5 3.0 
Tmax (h)2.0 4.0 
AUC0–∞(μg · h/ml)89.458.6 43.0 
t1/2 (h)7.0
Bioavailability (%)65.6 48.0 
Monkey (2)Cmax(μg/ml)1.1 0.4 (18)b
Tmax (h)14.0 5.0 (31)
AUC0–∞(μg · h/ml)115.059.4 15.9 (20)
t1/2 (h)22.7
Bioavailability (%)51.7 13.8 
  • a Values in parentheses are CVs (in percent).

  • b n = 6.