Table 2.

Comparative antibacterial activities against β-lactamase producers

Enzyme produced and organismMIC (μg/ml)a
J-111,347J-111,225J-114,870J-114,871ImipenemBiapenemMeropenemAztreonamCeftazidimeCefazolinAmpicillin
Penicillinase
E. coli ML4901 (TEM-1)0.0310.0310.0630.0310.1250.0630.0130.0630.1252>128
E. coli ML4901 (PSE-1)0.0160.0310.0310.0310.1250.0310.0160.1250.252>128
E. coli ML4901 (OXA-1)0.0310.0630.0630.0630.250.1250.0310.250.252128
Cephalosporinase
E. coliGN54820.0160.0310.0310.0310.1250.0310.016226464
M. morganiiGN54070.1250.1250.1250.06320.50.0310.0080.125128128
C. freundiiGN3460.0630.1250.1250.0630.250.1250.0633264>128>128
E. cloacaeGN74710.0630.1250.1250.1250.50.50.063832>128>128
P. aeruginosaGN103620.50.50.5111141>128>128
Oxyiminocephalosporinase
Klebsiella oxytocaGN106500.0630.0630.0630.0630.250.0630.03180.125>128128
P. vulgarisGN79190.1250.1250.1250.1250.50.250.031126464
B. cepaciaGN11164248882420.5>128>128
Carbapenemase
P. aeruginosaGN17203 (IMP-1)16323264128>1281282>128>128>128
Stenotrophomonas maltophilia GN12873 (L1, L2)3212812864128>12832>12816>128128
  • a Determined by the broth microdilution method.