Table 3.

Single- versus multiple-dose pharmacokinetics of SCH 56592 in fed dogs following daily administration in an MC suspension of 40 mg/kg for 8 consecutive days

Parameter (unit)Mean (% CV; n = 5)
Single dosea (day 1)Multiple dose (day 8)
Cmax(μg/ml)2.1 (31)5.6 (43)
Tmax (h)9.2 (90)5.0 (45)
AUC (μg · h/ml)105.0 (30)b107.0 (47)c
  • a These data are from the dose-response study (Table 2).

  • b AUC0–∞.

  • c AUC0–24.