Table 1.

Pharmacokinetic parameters of foscarnet after intravenous administration of 120 mg/kg to rabbits

Parameter (unite)aValue (mean ± SD)
Concn (μg/ml)
 0 h872 ± 120
 Maximum in peripheral compartment343 ± 92
A 0 490 ± 45
B 0 382 ± 75
Phase (h−1)
 α10.02 ± 0.24
 β0.636 ± 0.12
t 1/2(h)
 α0.065 ± 0.001
 β1.09 ± 0.26
t ss (h)0.37 ± 0.078
V (ml/kg)
V c 137.6 ± 22
V p 132.4 ± 14.2
V ss 270 ± 37
CL (ml/kg/min)2.86 ± 0.91
k(h−1)
k 1–2 4.57 ± 0.01
k 2–1 4.47 ± 0.12
k el 1.34 ± 0.2
AUC (μg · h/ml)
 AUC0–2 484 ± 166
 AUC0–∞ 649 ± 38
  • a t 1/2, half-life;t ss, time in steady state;V c, V p, andV ss, volume of distribution in the central or peripheral compartment or at steady state, respectively; CL, clearance;k, rate constant; k el, elimination rate constant.