Table 1.

Pharmacokinetic parameters of foscarnet after intravenous administration of 120 mg/kg to rabbits

Parameter (unite)aValue (mean ± SD)
Concn (μg/ml)
 0 h872 ± 120
 Maximum in peripheral compartment343 ± 92
A0490 ± 45
B0382 ± 75
Phase (h−1)
 α10.02 ± 0.24
 β0.636 ± 0.12
t1/2(h)
 α0.065 ± 0.001
 β1.09 ± 0.26
tss (h)0.37 ± 0.078
V (ml/kg)
Vc137.6 ± 22
Vp132.4 ± 14.2
Vss270 ± 37
CL (ml/kg/min)2.86 ± 0.91
k(h−1)
k1–24.57 ± 0.01
k2–14.47 ± 0.12
kel1.34 ± 0.2
AUC (μg · h/ml)
 AUC0–2484 ± 166
 AUC0–∞649 ± 38
  • a t1/2, half-life;tss, time in steady state;Vc, Vp, andVss, volume of distribution in the central or peripheral compartment or at steady state, respectively; CL, clearance;k, rate constant; kel, elimination rate constant.