Table 2.

Mean pharmacokinetic parameters of SCH 56592 following p.o. administration in MC suspensions

Species (n)Dose (mg/kg)Cmax (μg/ml)Tmax(h)AUC0–∞ (μg · h/ml)
Mice (6)204.9 (20)a3.0 82.0 
4011.5 (45)7.0 146.0 
8012.1 (20)7.0 363.0 
16017.1 (14)12.0 508.0 
Rats (3)102.7 (51)4.0 31.4 
203.7 (12)6.0 65.1 
406.0 (19)4.0 119.0 
8010.2 (26)6.0 189.9 
12010.1 (11)4.0 262.6 
Rabbits (6)204.2 (12)5.1 (21)77.5 (16)
Dogs (fasting) (5)100.2 (22)7.6 (121)7.5 (45)
Dogs (fed) (6)100.7 (28)8.3 (93)26.6 (42)
402.1 (31)9.2 (90)105.0 (30)
803.1 (20)9.0 (82)167.0 (18)
1203.3 (27)15.0 (66)192.0 (34)
  • a Values in parentheses are CVs (in percent).