Table 3.

Mechanisms of resistance in H. influenzaestrains for which quinolone MICs were increased

StrainMIC (μg/ml)Mutation
GemifloxacinCiprofloxacinLevofloxacinSparfloxacinGrepafloxacinTrovafloxacinParCParEGyrAGyrB
10.030.50.50.250.251S133-A, N138-SNoneS84-LNone
20.1250.250.250.250.50.25NoneS458-LS84-FNone
30.125110.50.51S84-INoneS84-LNone
40.2510.50.2520.5D83-NExtra Sa S84-F, D88-NQ468-R
50.2511111E88-KG405-SS84-YNone
60.522114S84-RD420-NS84-L, A117-ENone
70.522114S84-RD420-NS84-L, A117-ENone
80.522114S84-RD420-NS84-L, A117-ENone
9184848S84-R, N138-SS458-A, S474-NS84-F, D88-YNone
  • a In-frame insertion in parEleading to insertion of serine between the serine at position 458 and the threonine at position 459.