Table 1.

Comparative in vitro activities against clinical isolates

Organism (no. of isolates) and antibioticMIC (μg/ml)a
MRSA (26)
 J-111,3470.5–422
 J-111,2250.5–424
 J-114,8701–424
 J-114,8710.5–424
 Imipenem16–12864128
 Meropenem8–643264
 Biapenem16–1286464
 Vancomycin0.5–211
Staphylococcus aureus, methicillin susceptible (21)
 J-111,3470.008–0.016≤0.0080.016
 J-111,2250.008–0.0160.0160.016
 J-114,8700.008–0.0160.0160.016
 J-114,8710.008–0.0320.0160.016
 Imipenem0.008–0.0160.0160.016
 Meropenem0.032–0.1250.0630.125
 Biapenem0.016–0.0630.0320.063
 Ceftazidime4–848
 Vancomycin0.5–10.50.5
Coagulase-negative staphylococci, methicillin resistant (25)
 J-111,3470.125–40.52
 J-111,2250.125–414
 J-114,8700.125–414
 J-114,8710.125–414
 Imipenem0.125–12816128
 Meropenem1–1281664
 Biapenem0.5–12816128
 Ceftazidime8–>12864>128
 Vancomycin0.5–212
Streptococcus pyogenes(30)
 J-111,347≤0.008≤0.008≤0.008
 J-111,225≤0.008≤0.008≤0.008
 J-114,870≤0.008≤0.008≤0.008
 J-114,871≤0.008≤0.008≤0.008
 Imipenem≤0.008≤0.008≤0.008
 Meropenem≤0.008≤0.008≤0.008
 Biapenem≤0.008≤0.008≤0.008
 Ceftazidime0.063–0.1250.0630.125
 Penicillin G≤0.008≤0.008≤0.008
 Vancomycin 0.5  0.50.5
Streptococcus agalactiae(24)
 J-111,3470.008–0.016≤0.0080.016
 J-111,2250.008–0.016≤0.0080.016
 J-114,8700.008–0.0160.0160.016
 J-114,8710.008–0.0320.0160.016
 Imipenem0.008–0.016≤0.0080.016
 Meropenem0.016–0.0630.0320.032
 Biapenem0.008–0.0320.0160.032
 Ceftazidime0.5–10.50.5
 Penicillin G0.032–0.1250.0320.063
 Vancomycin0.5–111
Streptococcus pneumoniae, including penicillin-resistant organisms (32)
 J-111,3470.004–0.250.0080.25
 J-111,2250.004–0.250.0160.25
 J-114,8700.004–0.250.0160.25
 J-114,8710.004–0.250.0160.25
 Imipenem0.004–0.250.0160.25
 Meropenem0.008–0.50.0320.5
 Biapenem0.008–0.50.0160.25
 Ceftazidime0.125–16216
 Penicillin G0.008–20.1252
 Vancomycin0.25–0.50.50.5
Enterococcus faecalis(26)
 J-111,3471–828
 J-111,2251–1648
 J-114,8701–848
 J-114,8712–1648
 Imipenem0.5–414
 Meropenem4–32816
 Biapenem2–16816
 Ceftazidime>128>128>128
 Ampicillin0.5–414
 Vancomycin0.5–422
Enterococcus faecium (17)
 J-111,3472–>12832>128
 J-111,2254–>12832>128
 J-114,8704–>12864>128
 J-114,8714–>12864>128
 Imipenem4–>12864>128
 Meropenem16–>128128>128
 Biapenem16–>128>128>128
 Ceftazidime>128>128>128
 Ampicillin1–>12832128
 Vancomycin1–424
Escherichia coli (29)
 J-111,3470.016–0.0320.0160.032
 J-111,2250.016–0.0630.0320.032
 J-114,8700.016–0.0320.0160.016
 J-114,8710.016–0.0630.0320.032
 Imipenem0.032–0.1250.0630.125
 Meropenem0.016–0.0160.0160.016
 Biapenem0.016–0.0630.0320.063
 Ceftazidime0.063–160.0630.125
Klebsiella pneumoniae(25)
 J-111,3470.016–0.0630.0320.032
 J-111,2250.016–0.0630.0320.063
 J-114,8700.016–0.0630.0320.063
 J-114,8710.016–0.0630.0320.063
 Imipenem0.063–0.50.1250.25
 Meropenem≤0.008–0.0320.0160.032
 Biapenem0.032–10.0630.5
 Ceftazidime0.032–40.0630.25
Enterobacter cloacae(27)
 J-111,3470.032–0.50.0630.5
 J-111,2250.032–10.0630.5
 J-114,8700.032–20.0631
 J-114,8710.016–10.0320.5
 Imipenem0.063–10.51
 Meropenem0.016–40.0322
 Biapenem0.032–20.1251
 Ceftazidime0.125–>1280.5>128
Enterobacter aerogenes(23)
 J-111,3470.032–0.50.0630.125
 J-111,2250.032–10.1250.25
 J-114,8700.016–10.0630.25
 J-114,8710.032–10.1250.5
 Imipenem0.25–20.51
 Meropenem0.032–10.0630.25
 Biapenem0.063–10.251
 Ceftazidime0.063–>1280.564
Citrobacter freundii(22)
 J-111,3470.016–0.250.0320.25
 J-111,2250.032–0.50.0630.25
 J-114,8700.016–0.50.0320.5
 J-114,8710.016–0.50.0320.5
 Imipenem0.063–10.251
 Meropenem≤0.008–20.0161
 Biapenem0.032–10.1250.5
 Ceftazidime0.063–>1280.5>128
Citrobacter diversus(17)
 J-111,3470.016–0.1250.0320.063
 J-111,2250.016–0.250.0320.063
 J-114,8700.016–0.1250.0320.063
 J-114,8710.016–0.250.0320.063
 Imipenem0.063–0.50.1250.25
 Meropenem≤0.008–0.50.0160.125
 Biapenem0.016–0.1250.0320.125
 Ceftazidime0.032–160.0630.5
Proteus mirabilis(24)
 J-111,3470.063–10.1250.25
 J-111,2250.063–10.250.5
 J-114,8700.032–10.1250.25
 J-114,8710.063–10.250.5
 Imipenem0.5–424
 Meropenem0.032–0.1250.0320.063
 Biapenem1–424
 Ceftazidime0.016–0.0630.0320.032
Proteus vulgaris(24)
 J-111,3470.032–0.250.1250.25
 J-111,2250.063–0.50.1250.25
 J-114,8700.032–0.250.1250.25
 J-114,8710.063–0.50.1250.25
 Imipenem0.5–422
 Meropenem0.032–0.0630.0320.063
 Biapenem0.125–212
 Ceftazidime0.016–160.0634
Providencia rettgeri(25)
 J-111,3470.032–0.250.1250.25
 J-111,2250.032–0.50.1250.25
 J-114,8700.032–0.250.1250.25
 J-114,8710.063–0.50.1250.25
 Imipenem0.25–212
 Meropenem0.016–0.1250.0320.063
 Biapenem0.125–10.51
 Ceftazidime0.016–0.50.0320.063
Morganella morganii(21)
 J-111,3470.125–10.250.5
 J-111,2250.125–10.51
 J-114,8700.25–20.52
 J-114,8710.125–20.251
 Imipenem1–444
 Meropenem0.063–20.1250.125
 Biapenem1–414
 Ceftazidime0.032–1280.12516
Serratia marcescens(28)
 J-111,3470.032–10.0630.5
 J-111,2250.032–10.0630.5
 J-114,8700.063–20.0631
 J-114,8710.032–20.0631
 Imipenem0.125–40.250.5
 Meropenem0.016–40.0321
 Biapenem0.063–40.250.5
 Ceftazidime0.063–320.1254
Moraxella catarrhalis(25)
 J-111,347≤0.002–0.008≤0.008≤0.008
 J-111,225≤0.002–0.016≤0.008≤0.008
 J-114,870≤0.002–0.016≤0.008≤0.008
 J-114,871≤0.002–0.016≤0.008≤0.008
 Imipenem0.008–0.0630.0320.063
 Meropenem0.002–0.004≤0.008≤0.008
 Biapenem0.016–0.0630.0320.032
 Ceftazidime0.016–0.250.0630.125
Haemophilus influenzae(20)
 J-111,3470.032–0.250.0630.125
 J-111,2250.063–0.50.1250.125
 J-114,8700.063–0.50.1250.125
 J-114,8710.063–0.50.1250.125
 Imipenem0.25–211
 Meropenem0.032–0.1250.0630.063
 Biapenem0.25–411
 Ceftazidime0.032–0.250.1250.125
 Ampicillin0.125–640.251
Pseudomonas aeruginosa, imipenem susceptible (MIC, ≤4) (34)
 J-111,3470.125–80.54
 J-111,2250.125–1614
 J-114,8700.125–814
 J-114,8710.125–814
 Imipenem0.5–424
 Meropenem0.125–1614
 Biapenem0.25–412
 Ceftazidime0.5–>128116
Pseudomonas aeruginosa, imipenem resistant (MIC, ≥8) (38)
 J-111,3471–1648
 J-111,2252–32816
 J-114,8701–32416
 J-114,8712–64816
 Imipenem8–1281632
 Meropenem8–128816
 Biapenem1–>128816
 Ceftazidime1–>1288128
Acinetobacter spp. (21)
 J-111,347≤0.008–0.250.0320.125
 J-111,225≤0.008–0.50.0320.125
 J-114,8700.032–0.50.0630.25
 J-114,8710.016–0.50.0320.125
 Imipenem0.016–0.250.1250.125
 Meropenem0.032–0.250.1250.25
 Biapenem0.016–0.250.1250.25
 Ceftazidime0.5–3228
Burkholderia cepacia(21)
 J-111,3470.25–16816
 J-111,2250.5–32816
 J-114,8700.5–16816
 J-114,8710.5–32832
 Imipenem0.5–16416
 Meropenem0.032–814
 Biapenem0.125–828
 Ceftazidime0.5–>128216
Bacteroides fragilis(22)
 J-111,3470.125–0.50.250.5
 J-111,2250.25–10.250.5
 J-114,8700.125–10.250.5
 J-114,8710.25–10.250.5
 Imipenem0.063–20.50.5
 Meropenem0.063–40.250.25
 Biapenem0.125–40.250.5
 Ceftazidime4–>12816>128
Clostridium difficile(21)
 J-111,3470.5–111
 J-111,2251–222
 J-114,8701–222
 J-114,8711–222
 Imipenem4–1688
 Meropenem0.5–412
 Biapenem4–16816
 Ceftazidime32–>128128>128
  • a Determined by the broth microdilution method.