Table 1.

In vitro activity of macrolide antibiotics for S. oralis and S. mitis

OrganismAntibioticMIC (μg/ml)a
Range50%90%
S. oralisErythromycin0.016–>5120.1258
Clarithromycin0.016–20480.0318
Roxithromycin≤0.016–>5120.258
Azithromycin≤0.016–>5120.516
Rokitamycin0.031–40.1250.5
S. mitisErythromycin0.016–>5120.12532
Clarithromycin0.016–>5120.03132
Roxithromycin≤0.016–20480.12564
Azithromycin≤0.016–20480.564
Rokitamycin0.031–80.1251
  • a 50% and 90%, MIC50 and MIC90, respectively.