Table 1.

In vitro antiviral activities and cytotoxicities of 3TC, dOTC, and AZT in phytohemagglutinin-activated human PBMCs

DrugIC50(μM)a for:CC50(μM)a
NL4-3NL4-3/M184V
3TC0.09 ± 0.03 (4)85 ± 6.5 (2)830 ± 91 (3)
dOTC7.2 ± 4.2 (3)9.6 ± 7.5 (2)520 ± 49 (3)
AZT4.3 ± 2.2 × 10−5 (3)2.7 ± 0.3 × 10−5 (2)29 ± 11 (3)
  • a The IC50s and CC50s were calculated from dose-response curves obtained by linear regression of the percent control optical density (for either p24 or MTT) with eight drug concentrations assayed in triplicate wells. Data are presented as means ± standard errors for the numbers of independent experiments shown in parentheses.