Table 1.

Volume of ELF and AC counts at six time periods following drug administration

Characteristic4 h5 h7 h12 h24 h48 h
Total cell count in BAL fluida (cells/liter)1.31 × 108 ± 7.57 × 1071.72 × 108 ± 1.18 × 1081.41 × 108 ± 1.71 × 1089.94 × 107 ± 1.60 × 1078.52 × 107 ± 2.67 × 1079.30 × 107 ± 6.62 × 107
 Neutrophilsa(%)1.0 ± 1.21.6 ± 0.90.8 ± 0.80.8 ± 0.81.0 ± 1.01.4 ± 1.1
 Lymphocytes (%)11.2 ± 8.611.4 ± 6.822.6 ± 10.88.8 ± 5.79.0 ± 8.618.4 ± 10.3
 Monocytes/macrophages (%)86.0 ± 11.884.6 ± 7.676.2 ± 11.784.8 ± 9.589.6 ± 9.070.8 ± 21.7
 Eosinophils (%)0.8 ± 1.81.4 ± 2.20.4 ± 0.92.0 ± 4.50.4 ± 0.50.4 ± 0.5
 Degenerated cells (%)1.0 ± 2.21.0 ± 2.20.0 ± 0.03.6 ± 8.00.0 ± 0.09.0 ± 11.6
ELF vola(ml)0.82 ± 0.631.00 ± 0.351.21 ± 0.570.98 ± 0.391.13 ± 1.190.81 ± 0.48
BAL volb(ml)71 ± 8.279.8 ± 7.477 ± 7.277.6 ± 3.078.2 ± 11.779.8 ± 7.5
  • a The differences in AC count, differential cell count, or ELF volume among the six groups were not significant (P > 0.05).

  • b Mean ± SD for pooled volume of BAL fluid recovered.