Table 2.

Reproducibility of drug susceptibility determinationa

Virus and statisticNRTI IC50(μM)NNRTI IC50 (nM)PRI IC50 (nM)
ZDVddId4TddC3TCABCADVNVPDLVEFVSQVIDVRTVNFVAMP
CNDO
 Mean IC50 0.0304.570.660.681.771.741.3878.032.02.03.06.014.03.012.0
 SD0.0051.040.130.230.480.500.2811.06.60.30.70.92.10.72.4
 95% CI0.0030.570.070.120.260.270.156.03.60.20.40.51.10.41.3
R268
 Mean IC50 2.819.961.961.60>30022.173.263,817.9807.332.2470.3338.0>3.0163.852.3
 SD1.182.660.570.52NAb 10.370.851,379.0248.08.0134.764.4NA42.312.3
 95% CI0.641.450.310.28NA5.640.46749.4134.94.573.235.0NA23.06.7
  • a The mean IC50 of each drug, standard deviation (SD; derived from 13 independent determinations), and 95% confidence interval (CI; derived from 13 independent determinations) are listed for drug-sensitive (strain CNDO) and multidrug-resistant (strain R268) reference viruses. The multidrug-resistant reference virus contains RT mutations M41L, D67N, K103N, M184V, L210W, T215Y, and K219Q and PR mutations L10I, M36I, L63P, A71V, and V82T.

  • b NA, not applicable.