Table 1.

MICs for 248 H. influenzae and 50 M. catarrhalis (all quinolone susceptible) strains determined by the broth microdilution method

DrugMIC (μg/ml)
ß-Lactamase-positive H. influenzae(n = 101)aß-Lactamase-negative H. influenzae (n = 147)AllH. influenzae strains (n = 248)M. catarrhalis (n = 50)
Range50%90%Range50%90%Range50%90%Range50%90%
Gemifloxacin0.004–0.060.0080.0160.004–0.030.0080.0160.004–0.060.0080.0160.008–0.030.0160.016
Ciprofloxacin0.008–0.030.0160.0160.008–0.120.0160.0160.008–0.120.0160.0160.016–0.060.030.03
Levofloxacin0.016–0.030.030.030.008–0.120.030.030.008–0.120.030.030.016–0.060.060.06
Sparfloxacin0.008–0.1250.0160.030.008–0.060.0160.030.008–0.120.0160.030.016–0.060.030.03
Grepafloxacin0.002–0.030.0080.0080.002–0.030.0080.0080.002–0.030.0080.0080.004–0.0160.0080.016
Trovafloxacin0.008–0.060.0160.030.008–0.060.0160.030.008–0.060.0160.030.016–0.030.030.03
Ampicillin1.0–>16.0>16.0>16.0≤0.12–2.00.250.5≤0.12–>16.00.25>16.00.125–16.04.08.0
Amoxicillin2.0–>16.0>16.0>16.00.25–4.00.51.00.25–>16.00.5>16.00.125–16.04.08.0
Amoxicillin-clavulanate0.25–4.01.02.00.25–4.00.51.00.25–4.00.52.00.125–0.50.1250.25
Cefixime≤0.008–0.120.030.030.016–0.120.030.03≤0.008–0.120.030.030.03–0.50.250.25
Cefuroxime0.25–8.00.52.0≤0.25–16.00.52.0≤0.25–16.00.52.00.25–4.02.02.0
Azithromycin0.25–4.02.04.00.25–4.02.04.00.25–4.02.04.00.060.060.06
  • a n, number of strains.