Table 3.

Results of time-kill assays of 12 pneumococcal strains

Drug and concnNo. of strains killed by time point, with Δlog10 CFU/ml (from time zero value) of:
3 h6 h12 h24 h
−1−2−3−1−2−3−1−2−3−1−2−3
GAR-936
 8× MIC731126412117121212
 4× MIC621126412106121211
 2× MIC52111531296121111
 MIC4117521084121111
 0.5× MIC000300321532
Tetracyclinea
 8× MIC310533543665
 4× MIC200430542665
 2× MIC200320522655
 MIC100200320331
 0.5× MIC000000100000
Minocyclinea
 8× MIC421442544655
 4× MIC311432543655
 2× MIC210422543654
 MIC200320532643
 0.5× MIC100100000000
Doxycyclinea
 8× MIC420533553655
 4× MIC310530553655
 2× MIC100410541654
 MIC100210211222
 0.5× MIC000100100000
Amoxicillin
 8× MIC104012106121210121212
 4× MIC920119312128121212
 2× MIC830118212127121212
 MIC520114210531088
 0.5× MIC100210110211
Ceftriaxone
 8× MIC80012100121210121212
 4× MIC810129112118121212
 2× MIC800107012108121212
 MIC510960107110108
 0.5× MIC200200110000
Clarithromycinb
 8× MIC420740744776
 4× MIC310630744766
 2× MIC310431744766
 MIC210420643764
 0.5× MIC100200210211
Imipenem
 8× MIC124012102121110121212
 4× MIC11501292121110121212
 2× MIC11301294121110121212
 MIC102012821210811119
 0.5× MIC800630420332
Meropenem
 8× MIC1131125212129121212
 4× MIC920124212127121211
 2× MIC640127312118121211
 MIC621115211951098
 0.5× MIC100200100211
Vancomycin
 8× MIC710126112119121212
 4× MIC710126212109121211
 2× MIC710126212108121211
 MIC610124011951097
 0.5× MIC000200200220
  • a Only strains with tetracycline MICs of <8.0 μg/ml were tested.

  • b Only strains with clarithromycin MICs of <4.0 μg/ml were tested.