Table 1.

Susceptibilities of 8,796 clinical isolates to the seven fluoroquinolones tested

Organism(s) (no. of strains) and antimicrobial agentMIC (μg/ml)
Escherichia coli (411)
  Sitafloxacin≤0.008–4≤0.0081
  Ciprofloxacin≤0.008–>160.01516
  Trovafloxacin≤0.008–>160.015>16
  Levofloxacin≤0.008–>160.038
  Clinafloxacin≤0.008–8≤0.0081
  Gatifloxacin≤0.008–>160.038
  Moxifloxacin0.015–>160.0616
Klebsiella pneumoniae (445)
  Sitafloxacin≤0.008–80.0150.12
  Ciprofloxacin≤0.008–>160.030.5
  Trovafloxacin≤0.008–>160.060.5
  Levofloxacin0.015–>160.060.5
  Clinafloxacin≤0.008–160.0150.12
  Gatifloxacin0.015–>160.061
  Moxifloxacin0.03–>160.121
Klebsiella oxytoca (241)
  Sitafloxacin≤0.008–80.0150.03
  Ciprofloxacin≤0.008–160.0150.06
  Trovafloxacin0.015–160.030.12
  Levofloxacin0.015–80.060.12
  Clinafloxacin≤0.008–20.0150.03
  Gatifloxacin0.015–160.060.12
  Moxifloxacin0.03–160.120.25
Proteus mirabilis (319)
  Sitafloxacin≤0.008–>160.030.5
  Ciprofloxacin0.015–>160.034
  Trovafloxacin0.03–>160.2516
  Levofloxacin0.03–>160.064
  Clinafloxacin≤0.008–160.030.5
  Gatifloxacin0.06–>160.254
  Moxifloxacin0.12–>160.516
Proteus vulgaris (39)
  Sitafloxacin≤0.008–10.030.12
  Ciprofloxacin0.015–80.030.06
  Trovafloxacin0.03–80.251
  Levofloxacin0.015–80.030.12
  Clinafloxacin≤0.008–10.030.06
  Gatifloxacin0.06–160.250.5
  Moxifloxacin0.06–>160.51
Serratia marcescens (211)
  Sitafloxacin≤0.008–40.060.5
  Ciprofloxacin0.015–>160.122
  Trovafloxacin0.03–>160.54
  Levofloxacin0.03–>160.122
  Clinafloxacin≤0.008–80.060.25
  Gatifloxacin0.015–>160.252
  Moxifloxacin0.03–>160.54
Serratia liquefaciens (14)
  Sitafloxacin≤0.008–0.12≤0.0080.03
  Ciprofloxacin≤0.008–0.50.030.03
  Trovafloxacin≤0.008–0.120.060.06
  Levofloxacin0.015–10.030.06
  Clinafloxacin≤0.008–0.12≤0.0080.03
  Gatifloxacin0.015–10.060.12
  Moxifloxacin0.015–20.060.12
Citrobacter freundii (109)
  Sitafloxacin≤0.008–40.030.5
  Ciprofloxacin≤0.008–>160.0152
  Trovafloxacin≤0.008–>160.064
  Levofloxacin0.03–>160.062
  Clinafloxacin≤0.008–40.030.25
  Gatifloxacin0.015–>160.064
  Moxifloxacin0.03–>160.124
Citrobacter koseri (72)
  Sitafloxacin≤0.008–0.5≤0.0080.03
  Ciprofloxacin≤0.008–80.0150.03
  Trovafloxacin≤0.008–40.0150.06
  Levofloxacin0.015–40.030.12
  Clinafloxacin≤0.008–0.5≤0.0080.03
  Gatifloxacin0.015–20.030.06
  Moxifloxacin≤0.008–20.060.12
Enterobacter aerogenes (192)
  Sitafloxacin≤0.008–80.031
  Ciprofloxacin≤0.008–>160.06>16
  Trovafloxacin≤0.008–>160.06>16
  Levofloxacin0.03–>160.1216
  Clinafloxacin≤0.008–80.032
  Gatifloxacin0.015–>160.1216
  Moxifloxacin0.03–>160.12>16
Enterobacter cloacae (378)
  Sitafloxacin≤0.008–80.0150.25
  Ciprofloxacin≤0.008–>160.032
  Trovafloxacin≤0.008–>160.062
  Levofloxacin0.015–>160.062
  Clinafloxacin≤0.008–80.0150.25
  Gatifloxacin≤0.008–>160.061
  Moxifloxacin0.015–>160.122
Pantoea agglomerans (12)
  Sitafloxacin≤0.008–0.03≤0.0080.015
  Ciprofloxacin≤0.008–0.030.0150.03
  Trovafloxacin≤0.008–0.060.030.06
  Levofloxacin0.015–0.060.030.06
  Clinafloxacin≤0.008–0.06≤0.0080.015
  Gatifloxacin≤0.008–0.120.030.06
  Moxifloxacin0.015–0.120.060.12
Morganella morganii (138)
  Sitafloxacin≤0.008–160.0150.25
  Ciprofloxacin≤0.008–>160.0151
  Trovafloxacin0.015–>160.254
  Levofloxacin0.015–>160.061
  Clinafloxacin≤0.008–>160.0150.25
  Gatifloxacin0.03–>160.062
  Moxifloxacin0.03–>160.124
Providencia spp.a (31)
  Sitafloxacin≤0.008–20.52
  Ciprofloxacin0.015–>16416
  Trovafloxacin0.06–>1648
  Levofloxacin0.06–>16416
  Clinafloxacin≤0.008–40.51
  Gatifloxacin0.12–>1648
  Moxifloxacin0.25–>16816
Salmonellaeb (326)
  Sitafloxacin≤0.008–2≤0.0080.015
  Ciprofloxacin≤0.008–>160.0150.03
  Trovafloxacin≤0.008–160.030.06
  Levofloxacin≤0.008–80.060.06
  Clinafloxacin≤0.008–2≤0.0080.015
  Gatifloxacin≤0.008–80.030.06
  Moxifloxacin0.015–160.060.12
Shigellaspp.c (103)
  Sitafloxacin≤0.008–0.5≤0.0080.015
  Ciprofloxacin≤0.008–0.120.0150.03
  Trovafloxacin≤0.008–0.250.0150.03
  Levofloxacin0.015–0.060.030.03
  Clinafloxacin≤0.008–0.03≤0.008≤0.008
  Gatifloxacin≤0.008–0.250.030.03
  Moxifloxacin≤0.008–0.120.030.06
Yersinia enterocolitica (88)
  Sitafloxacin≤0.008–0.12≤0.0080.015
  Ciprofloxacin≤0.008–20.0150.03
  Trovafloxacin≤0.008–20.0150.06
  Levofloxacin≤0.008–10.030.06
  Clinafloxacin≤0.008–0.12≤0.0080.015
  Gatifloxacin≤0.008–0.50.0150.06
  Moxifloxacin≤0.008–10.030.06
Acinetobacter spp.d(428)
  Sitafloxacin≤0.008–812
  Ciprofloxacin0.015–>1616>16
  Trovafloxacin≤0.008–>16116
  Levofloxacin0.015–>16416
  Clinafloxacin≤0.008–1614
  Gatifloxacin≤0.008–>1648
  Moxifloxacin≤0.008–>16416
Burkholderia cepacia (47)
  Sitafloxacin0.015–80.254
  Ciprofloxacin0.25–>162>16
  Trovafloxacin0.06–>161>16
  Levofloxacin0.25–>162>16
  Clinafloxacin0.015–160.58
  Gatifloxacin0.12–>162>16
  Moxifloxacin0.12–>162>16
Pseudomonas aeruginosa (615)
  Sitafloxacin0.03–160.124
  Ciprofloxacin0.03–>160.25>16
  Trovafloxacin0.06–>160.5>16
  Levofloxacin0.12–>160.5>16
  Clinafloxacin0.03–160.124
  Gatifloxacin0.06–>161>16
  Moxifloxacin0.12–>162>16
Stenotrophomonas maltophilia (106)
  Sitafloxacin≤0.008–10.120.25
  Ciprofloxacin0.12–1624
  Trovafloxacin≤0.008–40.251
  Levofloxacin0.06–80.52
  Clinafloxacin≤0.008–20.120.5
  Gatifloxacin0.03–80.52
  Moxifloxacin≤0.008–40.251
Staphylococcus aureus
 Methicillin sensitive (434)
  Sitafloxacin≤0.008–40.0150.03
  Ciprofloxacin0.06–>160.250.5
  Trovafloxacin≤0.008–40.0150.03
  Levofloxacin0.06–>160.120.25
  Clinafloxacin≤0.008–20.030.03
  Gatifloxacin0.03–160.060.12
  Moxifloxacin0.015–40.060.06
 Methicillin resistant (457)
  Sitafloxacin0.015–80.250.5
  Ciprofloxacin0.12–>1616>16
  Trovafloxacin≤0.008–>1618
  Levofloxacin0.12–>16416
  Clinafloxacin0.015–40.51
  Gatifloxacin0.06–1644
  Moxifloxacin0.03–1624
Staphylococcus epidermidis
 Methicillin sensitive (214)
  Sitafloxacin≤0.008–0.50.0150.12
  Ciprofloxacin0.03–>160.2516
  Trovafloxacin0.015–80.031
  Levofloxacin0.12–160.124
  Clinafloxacin0.015–20.030.25
  Gatifloxacin0.06–40.122
  Moxifloxacin0.03–40.061
 Methicillin resistant (436)
  Sitafloxacin≤0.008–10.120.25
  Ciprofloxacin0.06–>164>16
  Trovafloxacin≤0.008–1614
  Levofloxacin0.03–>1648
  Clinafloxacin≤0.008–20.250.5
  Gatifloxacin0.015–1612
  Moxifloxacin≤0.008–1612
Staphylococcus haemolyticus
 Methicillin sensitive (15)
  Sitafloxacin≤0.008–0.120.0150.12
  Ciprofloxacin0.06–160.258
  Trovafloxacin0.015–20.0151
  Levofloxacin0.06–40.122
  Clinafloxacin0.015–0.250.030.12
  Gatifloxacin0.06–20.121
  Moxifloxacin0.03–10.061
 Methicillin resistant (125)
  Sitafloxacin0.015–20.251
  Ciprofloxacin0.12–>1616>16
  Trovafloxacin0.015–>16216
  Levofloxacin0.12–>168>16
  Clinafloxacin0.015–20.52
  Gatifloxacin0.06–1648
  Moxifloxacin0.06–828
Other CoNSe
 Methicillin sensitive (111)
  Sitafloxacin≤0.008–10.0150.12
  Ciprofloxacin0.06–>160.250.5
  Trovafloxacin≤0.008–160.030.25
  Levofloxacin0.06–>160.120.5
  Clinafloxacin0.015–20.030.12
  Gatifloxacin0.06–80.120.25
  Moxifloxacin0.03–80.120.5
 Methicillin resistant (102)
  Sitafloxacin≤0.008–40.030.25
  Ciprofloxacin0.06–>160.5>16
  Trovafloxacin0.015–160.064
  Levofloxacin0.06–>160.58
  Clinafloxacin0.015–40.060.5
  Gatifloxacin0.03–>160.254
  Moxifloxacin0.03–>160.122
Enterococcus faecalis
 Vancomycin sensitive (230)
  Sitafloxacin0.015–40.122
  Ciprofloxacin0.25–>161>16
  Trovafloxacin0.03–>160.258
  Levofloxacin0.25–>16116
  Clinafloxacin0.03–40.122
  Gatifloxacin0.06–>160.516
  Moxifloxacin0.06–>160.258
 Vancomycin resistant (27)
  Sitafloxacin0.03–20.122
  Ciprofloxacin0.25–>161>16
  Trovafloxacin0.06–160.2516
  Levofloxacin0.5–>161>16
  Clinafloxacin0.06–40.122
  Gatifloxacin0.12–>160.516
  Moxifloxacin0.06–160.2516
Enterococcus faecium
 Vancomycin sensitive (137)
  Sitafloxacin0.015–>160.54
  Ciprofloxacin0.12–>164>16
  Trovafloxacin0.03–>16216
  Levofloxacin0.25–>164>16
  Clinafloxacin0.03–>160.58
  Gatifloxacin0.06–>162>16
  Moxifloxacin0.06–>16216
 Vancomycin resistant (38)
  Sitafloxacin0.03–160.258
  Ciprofloxacin0.25–>162>16
  Trovafloxacin0.06–>16116
  Levofloxacin0.25–>162>16
  Clinafloxacin0.03–>160.2516
  Gatifloxacin0.12–>161>16
  Moxifloxacin0.12–>161>16
Streptococcus pneumoniae
 Penicillin sensitive (205)
  Sitafloxacin≤0.008–0.50.030.06
  Ciprofloxacin0.03–>1612
  Trovafloxacin≤0.008–80.120.25
  Levofloxacin0.12–>1611
  Clinafloxacin≤0.008–10.060.12
  Gatifloxacin≤0.008–80.250.5
  Moxifloxacin≤0.008–40.120.25
 Penicillin intermediate (93)
  Sitafloxacin0.015–0.50.030.06
  Ciprofloxacin0.5–>1612
  Trovafloxacin0.03–40.120.25
  Levofloxacin0.5–811
  Clinafloxacin0.015–10.060.12
  Gatifloxacin0.12–40.250.5
  Moxifloxacin0.06–20.120.25
 Penicillin resistant (129)
  Sitafloxacin0.015–0.50.030.06
  Ciprofloxacin0.25–>1612
  Trovafloxacin0.06–80.120.25
  Levofloxacin0.5–1611
  Clinafloxacin0.015–0.50.060.12
  Gatifloxacin0.12–80.250.5
  Moxifloxacin0.03–40.120.25
Beta-hemolytic streptococcif(454)
  Sitafloxacin≤0.008–0.120.060.03
  Ciprofloxacin0.12–40.51
  Trovafloxacin≤0.008–0.50.120.25
  Levofloxacin0.12–40.51
  Clinafloxacin≤0.008–0.50.060.12
  Gatifloxacin0.06–10.250.5
  Moxifloxacin≤0.008–10.120.25
Viridans group streptococcig (97)
  Sitafloxacin≤0.008–0.250.030.12
  Ciprofloxacin0.12–1614
  Trovafloxacin0.03–0.50.120.25
  Levofloxacin0.12–411
  Clinafloxacin0.015–0.50.060.12
  Gatifloxacin0.06–20.250.5
  Moxifloxacin0.015–0.50.120.25
Streptococcus milleri (40)
  Sitafloxacin≤0.008–0.060.030.03
  Ciprofloxacin0.25–10.51
  Trovafloxacin0.03–0.250.120.12
  Levofloxacin0.25–10.50.5
  Clinafloxacin0.015–0.120.060.06
  Gatifloxacin0.06–0.50.250.25
  Moxifloxacin≤0.008–0.250.120.25
Haemophilus influenzae (224)
  Sitafloxacin≤0.008–0.03≤0.008≤0.008
  Ciprofloxacin≤0.008–0.03≤0.0080.015
  Trovafloxacin≤0.008–0.25≤0.008≤0.008
  Levofloxacin≤0.008–0.060.0150.015
  Clinafloxacin≤0.008–0.03≤0.008≤0.008
  Gatifloxacin≤0.008–0.25≤0.0080.015
  Moxifloxacin≤0.008–0.250.0150.03
Moraxella catarrhalis (213)
  Sitafloxacin≤0.008–0.03≤0.008≤0.008
  Ciprofloxacin0.015–10.030.03
  Trovafloxacin≤0.008–0.060.0150.015
  Levofloxacin0.03–0.50.030.06
  Clinafloxacin≤0.008–0.06≤0.0080.015
  Gatifloxacin0.015–0.250.030.03
  Moxifloxacin≤0.008–0.120.060.06
Neisseria meningitidis (99)
  Sitafloxacin≤0.008–0.015≤0.008≤0.008
  Ciprofloxacin≤0.008–≤0.008≤0.008≤0.008
  Trovafloxacin≤0.008–0.015≤0.008≤0.008
  Levofloxacin≤0.008–≤0.008≤0.008≤0.008
  Clinafloxacin≤0.008–0.015≤0.008≤0.008
  Gatifloxacin≤0.008–0.015≤0.008≤0.008
  Moxifloxacin≤0.008–0.015≤0.008≤0.008
Neisseria gonorrhoeae (185)
  Sitafloxacin≤0.008–0.12≤0.008≤0.008
  Ciprofloxacin≤0.008–8≤0.008≤0.008
  Trovafloxacin≤0.008–4≤0.008≤0.008
  Levofloxacin≤0.008–4≤0.008≤0.008
  Clinafloxacin≤0.008–0.25≤0.008≤0.008
  Gatifloxacin≤0.008–2≤0.008≤0.008
  Moxifloxacin≤0.008–4≤0.0080.015
Bacteroides fragilis group (157)
  Sitafloxacin0.03–>160.121
  Ciprofloxacin2–>168>16
  Trovafloxacin0.06–160.52
  Levofloxacin0.5–>162>16
  Clinafloxacin0.06–>160.252
  Gatifloxacin0.25–>1618
  Moxifloxacin0.12–>1618
Bacteroides spp. (39)
  Sitafloxacin≤0.008–40.121
  Ciprofloxacin0.12–>1616>16
  Trovafloxacin0.06–>1618
  Levofloxacin0.12–>16416
  Clinafloxacin0.015–160.251
  Gatifloxacin0.06–>1618
  Moxifloxacin0.06–>1618
Clostridium difficile (143)
  Sitafloxacin0.03–10.120.12
  Ciprofloxacin2–16816
  Trovafloxacin0.12–811
  Levofloxacin1–1644
  Clinafloxacin0.12–10.250.25
  Gatifloxacin0.5–812
  Moxifloxacin0.25–812
Clostridium perfringens (20)
  Sitafloxacin0.015–0.060.060.06
  Ciprofloxacin0.25–111
  Trovafloxacin0.06–0.50.250.25
  Levofloxacin0.25–10.51
  Clinafloxacin0.06–0.120.120.12
  Gatifloxacin0.25–10.51
  Moxifloxacin0.25–10.51
Peptostreptococcus spp. (35)
  Sitafloxacin≤0.008–0.50.030.12
  Ciprofloxacin0.12–1614
  Trovafloxacin0.015–20.251
  Levofloxacin0.12–1614
  Clinafloxacin≤0.008–0.50.120.5
  Gatifloxacin0.06–80.52
  Moxifloxacin0.03–20.251
Prevotella spp. (12)
  Sitafloxacin≤0.008–0.250.060.25
  Ciprofloxacin1–>164>16
  Trovafloxacin0.12–10.51
  Levofloxacin0.5–414
  Clinafloxacin0.03–0.50.120.5
  Gatifloxacin0.25–40.52
  Moxifloxacin0.25–80.52
  • a Includes 22 P. stuartii, 1P. alcalifaciens, and 8 P. rettgeri strains.

  • b Includes 103 S. typhi entericaserovar and 223 other S. enterica strains.

  • c Includes 22 S. boydii, 15 S. dysenteriae, 48 S. flexneri, and 9 S. sonneistrains and 9 strains not identified to the species level.

  • d Includes 397 A. calcoaceticus-baumannii group, 1 A. junii, and 30A. lwoffii strains.

  • e Includes 50 S. auricularis, 56S. hominis, 31 S. capitis, 14 S. warneri, 9 S. cohnii, 11 S. saprophyticus, 7S. simulans, 3 S. sciuri, 3 S. xylosus, 1 S. lugdunensis, 1 S. schleiferi, 1 S. chromogenes, and 2 S. equorum strains and 24 coagulase-negative staphylococcal strains (CoNS) not identified to the species level.

  • f Includes 181 group A, 210 group B, 18 group C, and 45 group G strains.

  • g Includes 54 S. mitis, 12 S. salivarius, and 31 S. sanguis strains.