Table 2.

DHFR and DHPS genotypes of P. falciparumisolates collected before and after PM-SD treatment in Kilifi, Kenya, between 1997 and 1999

IsolatesGenotypea of indicated codon before treatmentGenotype of indicated codon after treatment
DHFRDHPSDHFRDHPS
10851591644364375405816131085159164436437540581613
−/Pf001NANANANANANANANANAMutMutMutMut
−/Pf014NANANANANANANANANAMutMutMutMutMut
−/Pf024NANANANANANANANANAMutMutMut
−/Pf026NANANANANANANANANAMutMutMut
−/pg128b NANANANANANANANANAMutMutMut
−/Pf039NANANANANANANANANAMutMutMutMix
−/107FNANANANANANANANANAMutMixMutMix
−/142c NANANANANANANANANAMutMutMutMut
−/L030NANANANANANANANANAMutMutMutMut
−/154FNANANANANANANANANAMutMutMixMutMut
269/Pf017MutMutMutMutMutMutMutMutMut
15/Pf021d MutMixMutMutMutMutMutMix
47/Pf042MutMixMixNDNDNDNDNDMixMixMix
L19/L19PMMutMixMixMutMutMutMixMixMutMut
L20/L20PMMutMutMutMixMutMutMutMutMut
L21/L21PMMutMutMixMutMutMutMutMutMutMut
L22/L22DPMNDNDNDNDMutMutNDNDNDNDMutMut
L23/L23PMNDNDNDNDMutMixMutMutMut
L24/L24PMMutMixMixMixMutMutMutMutMut
L25/L25PMMutMutMutMutMutMutMutMutMut
300/210FMutMixMixMutMutMutMutMutMut
206/206FMutMixMixMutMutMutMixMixMutMut
214/214FMutMutMutMutMutMutMutMutMut
286/286FMutMixMixMutMutMutMutMutMutMut
280/280FMutMixMixMutMutMutMutMutMut
285/285FMutMutMutMutMutMutMutMutMut
292/292FMutMutMixMutMutMutMutMutMutMut
281/281FMutMutMutMutMutMutMutMutMutMut
275/275FMutMutMutMutMut
219/219FNDNDNDNDMutMutMutMutMutMutMut
  • a NA, not available; Mut, mutated; —, wild type; Mix, mixed; ND, not determined. For trimorphic codon 436 of DHPS, the mutated codon is Phe and the mixed codons are Ala and Ser.

  • b Isolate collected after 28 days.

  • c Isolate collected after 14 days.

  • d Isolate collected after 16 days.