Compartment and parameter^{b} | Initial estimate | Population mean | Coefficient of variation^{c} | Distribution |
---|---|---|---|---|

Aqueous | ||||

V(liters)_{c}
| 175 | 174 | 4 | Normal |

k(h_{a}
^{−1}) | 1.99 | 2.06 | 39 | Normal |

t
_{1/2a} (h) | 0.35 | 0.34 | ||

k
_{el}(h^{−1}) | 0.17 | 0.13 | 44 | Normal |

t
_{1/2el} (h) | 4.1 | 5.3 | ||

k
_{pa} · V(h_{c}/V_{a}
^{−1}) | 0.052 | 0.045 | 14 | Log-normal |

k
_{ap}(h^{−1}) | 0.22 | 0.2 | 34 | Log-normal |

t
_{1/2ap} (h) | 3.2 | 3.5 | ||

K
| 0.24 | 0.23 | ||

Vitreous | ||||

V (liters)_{c}
| 175 | 171 | 4 | Normal |

k(h_{a}
^{−1}) | 1.99 | 2.18 | 39 | Normal |

t
_{1/2a} (h) | 0.35 | 0.32 | ||

k
_{el}(h^{−1}) | 0.17 | 0.14 | 39 | Normal |

t
_{1/2el} (h) | 4.1 | 4.9 | ||

k
_{pv} · V
_{c}/V_{vit}(h^{−1}) | 0.016 | 0.022 | 14 | Log-normal |

k
_{vp}(h^{−1}) | 0.054 | 0.13 | 34 | Log-normal |

t
_{1/2vp} (h) | 13 | 5.3 | ||

K
| 0.3 | 0.17 |

↵a Half-lives corresponding to the rate constants of the model are shown.

↵b t

_{1/2a}, half-life of absorption;*t*_{1/2el}, half-life of elimination;*t*_{1/2ap}, half-life of loss from the aqueous;*t*_{1/2vp}, half-life of loss from the vitreous. The other abbreviations are defined in the text.↵c Intersubject variability expressed as percent coefficient of variation of the population.