Table 1.

Pharmacokinetic parameters describing the time course of concentrations of ciprofloxacin in plasma and compartments of the eyea

Compartment and parameterbInitial estimatePopulation meanCoefficient of variationcDistribution
Aqueous
Vc (liters)1751744Normal
ka (h−1)1.992.0639Normal
t 1/2a (h)0.350.34
k el(h−1)0.170.1344Normal
t 1/2el (h)4.15.3
k pa · Vc/Va (h−1)0.0520.04514Log-normal
k ap(h−1)0.220.234Log-normal
t 1/2ap (h)3.23.5
K 0.240.23
Vitreous
Vc (liters)1751714Normal
ka (h−1)1.992.1839Normal
t 1/2a (h)0.350.32
k el(h−1)0.170.1439Normal
t 1/2el (h)4.14.9
k pv · Vc/V vit(h−1)0.0160.02214Log-normal
k vp(h−1)0.0540.1334Log-normal
t 1/2vp (h)135.3
K 0.30.17
  • a Half-lives corresponding to the rate constants of the model are shown.

  • b t1/2a, half-life of absorption; t 1/2el, half-life of elimination;t 1/2ap, half-life of loss from the aqueous;t 1/2vp, half-life of loss from the vitreous. The other abbreviations are defined in the text.

  • c Intersubject variability expressed as percent coefficient of variation of the population.