Table 2.

In vitro susceptibilities of C. neoformans to fluconazole and details of treatments and clinical outcomes for 25 patients

Patient no.Fluconazole MIC (μg/ml)Antifungal therapyaOutcome of therapy
10.25A + FL for 38 days and then FZ at 400 mg day on discharge (day 44)Cure
20.5A + FL for 7 days, then FZ at 400 mg/day for 7 days and then FZ at 400 mg on dischargeCure
31A + FL for 4 wk and then on day 7 FZ at 200 mg/day on dischargeCure
41A + FL for 7 days and then on day 7 FZ at 400 mg intravenouslyDied on day 11
51A for 29 days and then FZ at 400 mg/day on dischargeCure
61A + FL for 24 h and then FZ at 400 mg/dayDied on day 3
72A for 10 days and then on day 10 FZ at 400 mg/dayCure
82 & 4b A until a total dose of 1 g and then FZ at 400 mg/dayc Cure
94A until a total dose of 1 g and then FZ at 400 mg/daya Cure
104A + FL for 8 days and then FZ at 400 mg/day on dischargeCure
114A until a total dose of 1 g and then FZ at 400 mg/dayc Cure
124A + FL for 19 days and then FZ at 400 mg/dayCure
134A until a total dose of 1 g and then FZ at 400 mg/dayc Cure
144A until a total dose of 1 g and then FZ at 400 mg/dayc Cure
154 & 8b A until a total dose of 1 g and then FZ at 400 mg/dayc Cure
164 & 8b A until a total dose of 1 g and then FZ at 400 mg/dayc Cure
178A until a total dose of 1 g and then FZ at 400 mg/dayc Cure
188A until a total dose of 1 g and then FZ at 400 mg/dayc Cure
198A until a total dose of 1 g and then FZ at 400 mg/dayc Cure
208A until a total dose of 1 g and then FZ at 400 mg/dayc Cure
2116A until a total dose of 1 g and then FZ at 400 mg/dayc Failure (died, day 9)
22d 32A until a total dose of 1 g and then FZ at 400 mg/dayFailure
238→32e A until a total dose of 1 g and then FZ at 400 mg/dayc Failure (died, wk 6)
248→64e A until a total dose of 1 g and then FZ at 400 mg/dayc Failure (died, wk 10)
254→64e A until a total dose of 1 g and then FZ at 400 mg/dayc Failure (died, wk 5)
  • a A, amphotericin B; FL, flucytosine; FZ, fluconazole.

  • b MICs for isolates from blood and CSF, respectively.

  • c Patients were treated until the total dose of amphotericin B was achieved; treatment with fluconazole at 400 mg/day was continued for 8 to 10 weeks, and then the patient was maintained on fluconazole at 200 mg/day p.o.

  • d Currently treated with itraconazole (600 mg/day p.o.).

  • e Fluconazole MIC for initial and relapse isolates, respectively.