Table 2.

Broad-spectrum antimicrobial activity of IB-367 against oral flora by the modified NCCLS broth microdilution methoda

Group and organism (no. of strains)Prevalence range (%)bMIC range (μg/ml)
Gram-positive bacteria
 Viridans group streptococcic 93–99
  S. salivarius (12)50–750.2–5.0
  S. sanguis (14)25–754–64
  S. mitis (15)25–752–43
  S. mutans(3)25–750.7–1.3
Streptococcus spp., group D (6)90–1000.25–4
Streptococcus spp. (16)c 1–501.3–16
Corynebacterium spp. (5)c 15–900.13–0.25
Propionibacterium 11–12NTd
Staphylococcus spp. (35)3–700.13–4
Lactobacillus 1–37NT
Gram-negative bacteria
Moraxella spp. (12)81–970.2–0.8
Neisseria sp. (1)c 5–978
Haemophilus spp. (15)c 5–351–8
Acinetobacter calcoaceticus (4)5–300.06–2
Klebsiella pneumoniae (4)51–5
Pseudomonas aeruginosa(18)51–8
Escherichia coli(5)NAe 0.25–1
Serratia marcescens (16)NA16–>256
Yeast, Candida albicans(6)3–64–16
  • a Described in reference15.

  • b Adapted from Liljemark and Bloomquist (12).

  • c Addition of blood products (e.g., 2% LHB or hematin) is required for acceptable growth.

  • d NT, not tested.

  • e NA, not applicable.