Table 2.

Summary of analyses of significant effects of patient covariates tested alone in CL

HypothesisParameterization (CL/F)Null valueθ4 (95% CI)Change in objective functionP
Model 1 (do the following affect CL/F?)
 CD4 < 100 cells per μlθ1(1 − θ4 · cd4)00.19 (0.02, 0.36)10.014<0.01
 Concomitant medications
  Fluconazoleθ1(1 − θ4 · flu)00.26 (0.11, 0.40)17.225<0.01
  Macrolideθ1(1 − θ4 · mac)a 00.24 (0.02, 0.46)10.784<0.01
  Ribabutinθ1(1 + θ4 · rif)b 00.55 (0.32, 0.77)6.035<0.05
Model 2 (do the following affect CL/F?)
 CD4 < 100 cells per μlθ1(1 − θ4 · cd4)00.17 (0.01, 0.33)6.978<0.01
 Concomitant medications
  Fluconazoleθ1(1 − θ4 · flu)00.27 (0.15, 0.40)18.531<0.01
  Macrolideθ1(1 − θ4 · mac)00.23 (0.06, 0.41)10.132<0.01
  Rifabutinθ1(1 + θ4 · rif)00.37 (0.17, 0.57)3.012Not significant
  • a mac, value of 1 for concomitant macrolide therapy and 0 otherwise.

  • b rif, value of 1 for concomitant rifabutin therapy and 0 otherwise.