Table 1.

DXG-AZT mutational interactions

VirusDXG-susceptible virusesAZT-susceptible viruses
EC50(μM)aFold resistancebEC50 (μM)Fold resistance
HIV-1LAI 0.28 ± 0.040.003 ± 0.000
HIV-1LAIK65R2.41 ± 0.358.70.010 ± 0.0033.3
HIV-1LAIL74V1.17 ± 0.264.20.006 ± 0.0021.9
HIV-1LAI4×AZTc 0.58 ± 0.172.10.14 ± 0.0447.7
HIV-1LAI 4×AZT + K65R1.40 ± 0.165.00.004 ± 0.00041.3
HIV-1LAI 4×AZT + L74V1.04 ± 0.143.70.019 ± 0.0066.3
  • a EC50s were determined via the p24 antigen assay in MT-2 cells (see Materials and Methods). Values are means ± standard errors (n = 3 or 4 experiments).

  • b Fold resistance relative to the EC50 for the wild-type virus.

  • c AZT-resistant strain with mutations 67N, 70R, 215Y, and 219Q.