Table 1.

Characteristics of 174 patients evaluated in the population pharmacokinetic analysis of nelfinavir

CharacteristicNo. of patients% Total study population
Sex (men/women)155/1989/11
Mean age (range)37 (21–63)b
Mean total body weight (range)77.7 (42–140)c
Baseline CD4 count (cells per μl)
 <10035 20 
 <300 and >1005934 
 <3008046 
Baseline viral RNA (copies/ml)
 >100,0006839 
 >50,000 and <100,00043  25 
 >50,0006336 
Race
 Caucasian13678 
 Black2112 
 Asian 32 
 Hispanic 74 
 Latin American 42 
 Native American 32 
Concomitant medications
 Azole (fluconazole)25 (23)15 (13)
 Macrolide18  10 
 Quinolone128 
 Rifabutin 53 
History of liver disease6034 
LFTs grade 2 or higher5129 
Plasma M8-to-nelfinavir ratioa
 Low ratio (<0.1) 63 
 Intermediate ratio (>0.1 and <0.3)6738 
 High ratio (>0.3)37  21 
  • a M8 concentrations were available for only 110 of 174 patients in this study.

  • b In years.

  • c In kilograms.