Table 2.

Cross-resistance of HIV-1LAI encoding K65R

Antiviral agentMean EC50(μM)aFold resistanceb
ddC6.6 ± 1.93.1
ddI14.2 ± 3.63.1
D4T18.4 ± 6.33.0
3TC>60>14.2
PFA66.3 ± 3.23.0
d-ACPD12.9 ± 3.93.7
d-DAPD48.1 ± 8.94.5
d-FDOC2.6 ± 0.67.7
PMEA>60>4.3
  • a EC50s were determined by measurement of inhibition of p24 antigen production in MT-2 cells (see Materials and Methods). Values are means ± standard errors (n = 3 or 4 experiments).

  • b Fold resistance relative to the EC50 for the parental virus.