Table 1.

In vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against 140 A. baumannii isolates

AntibioticMIC (mg/liter)% of strains fully susceptiblea
Range50%90%Geometric mean
Ciprofloxacin≤0.03—>1280.56419.666.4
Clinafloxacin0.06—320.1241.379.3
Gatifloxacin≤0.03—1280.1283.771.4
Gemifloxacin≤0.03—320.12163.272.1
Levofloxacin≤0.03—320.2583.274.3
Moxifloxacin≤0.03—640.12164.273.6
Trovafloxacin≤0.03—320.06163.377.9
  • a MIC breakpoints for susceptibility are those defined by NCCLS for ciprofloxacin (≤1 mg/liter) and levofloxacin (≤2 mg/liter) for susceptibility testing of non-Enterobacteriaceae. For the other fluoroquinolone agents, no breakpoints have been established. For clinafloxacin (≤1 mg/liter), gatifloxacin (≤1 mg/liter), gemifloxacin (≤0.5 mg/liter), moxifloxacin (≤1 mg/liter), and trovafloxacin (≤1 mg/liter), the breakpoints suggested by the manufacturers were applied.