Table 2.

Effect of fluconazole on recovery of CFU from kidney tissue of C. albicans-infected mice

Isolate no.bFluconazole dose (mg/kg/day)CFU per g of kidney tissue (104) at day 6 sacrificePa for indicated pairs of doses (mg/kg/day)
MedianRange0 vs 10 vs 51 vs 5
1 (S)05741–73
110.9–1.4<0.005
50.530.32–0.74<0.005n.s.
2 (R)033740–630
1177120–235n.s.
5583300–1,100n.s.n.s.
3 (Rtr)0453.5–78
153.5–7.1<0.05
51.50.7–2.4<0.05<0.01
4 (Rtr)012763–192
10.440.3–0.6<0.025
50.080.05–0.11<0.025<0.005
  • a P values were obtained using Student's t test; n.s., not significant (P> 0.05).

  • b Interpretation of fluconazole susceptibilities as determined by the M27-A broth microdilution method are in parentheses. S, susceptible; Rtr, resistant with trailing growth; R, resistant.