Table 1.

Sequence across study days of MgSO4 and placebo doses for 12 subjects in a crossover design employing three replicated Latin squares

Subject no.Dose of MgSO4 (g)
Day 1Day 2Day 3Day 4
1123Placebo
231Placebo2
3Placebo321
42Placebo13
6132Placebo
7Placebo231
83Placebo12
91Placebo32
1023Placebo1
11Placebo213
12312Placebo
13a21Placebo3
  • a Subject no. 5 was removed from the study due to a protocol violation (dose sequence error) and reenrolled after a 2-day washout as subject no. 13 using the same dose sequence; data for subject no. 5 were excluded except those for adverse events.