Table 3.

Conservation of L4 sequences among gram-positive and gram-negative bacteriaa

OrganismPosition of beginning residueAmino acid sequencePosition of ending residue
Streptococcus pneumoniae59G G G R K P W R Q K G T G R A R Q G S I R S P Q W R G G G V V F90
Enterococcus faecalis59G G G R K P W R Q K G T G R A R Q G S I R S P Q W R G G G V V F90
Streptococcus pyogenes59G G G R K P W R Q K G T G R A R Q G S I R S P Q W R G G G V V F90
Staphylococcus aureus59G G G R K P W K Q K G T G R A R Q GT I R A P Q W R G G G I V F90
Staphylococcus epidermidis50G G G R K P W R Q K G T G R A R Q G T I R A P Q W R G G G V V F81
Streptococcus haemolyticus50G G G R K P W R Q K G T G R A R Q G T I R A P Q W R G G G I V F81
Escherichia coli54G S G K K P W R Q K G T G R A R S G S I K S P I W RS G G V T F85
Enterobacter cloacae54G S G K K P W R Q K G T G R A RS G S I K S P I W R S G G VT F85
Klebsiella pneumoniae54G SG K K P W R Q K G T G R A R S G S I KS P I W R S G G V T F85
Pseudomonas aeruginosa54G G G K K P W R Q K G T G R A R A G T I R S P I W RS G G T T F85
Morganella morganii54G S G K K P W R Q K G T G R A RS G S I K S P I W R S G GI T F85
Proteus mirabilis54G S GK K P W R Q K G T G R A R S G S I K S P I W R S G G G T F85
Yersinia pestis54G S G K K P W R Q K G T G R A RA G S V K S P I W R S G G VT F85
  • a Numbers at either end of the sequences refer to the amino acid positions of L4 in the individual species. The source of the S. pneumoniae and E. coli sequences were the TIGR website; the remainder of the sequences were courtesy of Incyte Pharmaceuticals. Boldface letters indicate residues that differ from the S. pneumoniae L4 sequence.