Table 2.

Efficacy of therapeutic and prophylactic administration of SCH against pulmonary Aspergillus infections in immunocompromised mice

StrainPD50 (mg/kg) on day 7
Therapeutic administration of SCHaProphylactic administration ofb:
SCHITC
A. fumigatus
 ND1523.62.2, 0.9c>75, >75c
 ND15829.92.6>75
 ND15910.9 NDdND
 ND16422.2NDND
A. flavus
 ND835.73.9, 9.0c>75, >75c
 ND1344.8NDND
 ND1496.5NDND
 ND1685.6NDND
  • a ITC was not tested therapeutically.

  • b The PD50 was based on the total daily dose.

  • c Results from experiments 1 and 2.

  • d ND, not done.