Table 1.

In vitro activities of SCH, ITC, and FLC againstAspergillus, Candida, and Cryptococcus

SpeciesNo. of isolatesMIC (μg/ml)
SCHITCFLC
Range50%90%Range50%90%Range50%90%
A. flavus11≤0.002–0.1250.0080.1250.008–0.250.1250.25 NDaNDND
A. fumigatus17≤0.002–0.062≤0.0020.0310.004–0.250.1250.25NDNDND
Aspergillusspeciesb11≤0.002–0.50.0160.5≤0.008–10.1250.5NDNDND
C. albicans156≤0.004–16≤0.0040.125NDNDND0.062–>640.12516
C. tropicalis20≤0.004–8≤0.0162NDNDND0.125–>640.25>64
C. glabrata20≤0.016–20.251NDNDND0.5–>64464
C. krusei200.062–0.50.250.5NDNDND8–643264
Candidaspeciesc59≤0.004–1≤0.0160.25NDNDND≤0.062–>640.2516
C. neoformans9≤0.016–0.50.062NDNDNDND≤0.062–162ND
  • a ND, not determined.

  • b Includes the following species and number of strains: A. niger, n = 5; A. terreus, n = 4; A. nidulans, n = 1; species not identified, n = 1.

  • c Includes the following species and number of strains: C. kefyr, n = 7; C. parapsilosis, n = 7; C. guilliermondii, n = 6; C. dubliniensis, n = 5; C. lusitaniae, n = 5; C. lambica, n = 3; C. rugosa, n = 3; C. famata, n = 2; C. inconspicua, n = 2; C. pseudotropicalis, n = 1; C. stellatoidea, n = 1; species not identified, n = 17.