Table 1.

Percent survival and PDs (day 28) for mice in the chronic suppression model of disseminated aspergillosisa

Treatment group% SurvivalPD50 (95% confidence interval)PD90 (95% confidence interval)
Study 1 Study 2 Study 3 Study 1Study 2Study 3Study 1Study 2Study 3
Caspofungin
 1.0 mg/kg80.050.092.00.328 (0.199, 0.522)0.400 (0.194, ∞)0.173 (0.136, 0.207)>1.0 (NC)>1.0 (NC)0.486 (0.389, 0.684)
 0.5 mg/kg80.0100.090.0
 0.25 mg/kg40.030.086.0
AmB
 1.0 mg/kg80.050.090.00.500 (0.314, ∞)0.600 (0.329, ∞)0.235 (0.189, 0.282)>1.0 (NC)>1.0 (NC)0.753 (0.582, ∞)
 0.5 mg/kg40.070.080.0
 0.25 mg/kg30.030.056.0
Infected, sham treated10.010.022.0
CY controls
 Sham infected, sham treated100.0100.095.0
 Noninfected, nontreated90.0100.0100.0
  • a Mice were challenged i.v. with A. fumigatus MF5668 at 1.0 × 104 CFU/mouse (study 1), at 2.4 × 104 CFU/mouse (study 2), and 1.88 × 104 CFU/mouse (study 3). Mice received the first treatment 24 h after challenge (delayed therapy) and were treated i.p., q.d., for 7 days. Mice were immunosuppressed throughout the experimental period (28 days). There were 10 mice per group in studies 1 and 2 and 50 mice per group in study 3, except for the CY control groups, which had 20 mice per group. PD50s and PD90s were calculated based on survival. NC, not calculated; ∞, infinitely large.