Effects of sequential therapy on fungal burdens of mice infected with C. neoformans 2337a
| Study no. | Therapy (dose [mg/kg/day]) | Log10 CFU/g in the following tissues: | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Lung | Brain | Kidney | Liver | Spleen | |||||||
| Mean | Range | Mean | Range | Mean | Range | Mean | Range | Mean | Range | ||
| 3 | None | 10.2 | 8.7–10.5 | 7.5 | 6.9–7.9 | 7.3 | 6.1–7.6 | 7.4 | 6.8–7.6 | 7.3 | 7.0–7.5 |
| FLC | 8.2b,c | 7.1–8.7 | 6.6b | 5.9–6.8 | 5.9b | 5.2–6.2 | 6.2b | 5.3–6.7 | 6.0b | 5.3–6.4 | |
| AmB | 10.6 | 7.8–11.2 | 6.6b | 5.7–7.1 | 5.4b | 4.5–5.7 | 6.3b | 5.7–6.7 | 6.5b | 4.8–6.9 | |
| FLC-AmB | 6.7b,d,e | 5.7–5.9 | 5.2b,d,e | 3.7–5.7 | 4.7b,d | 3.2–5.3 | 5.3b,e | 3.2–5.7 | 4.2b,d,e | 4.0–4.5 | |
| 4 | None | 8.0 | 7.7–8.3 | 7.4 | 6.7–7.8 | 6.8 | 5.7–7.4 | 6.9 | 6.1–7.4 | 7.0 | 6.8–7.3 |
| FLC | 7.7 | 7.0–8.0 | 7.3 | 6.6–7.7 | 6.6 | 5.8–7.1 | 6.8 | 5.9–7.2 | 6.9 | 5.7–7.2 | |
| AmB(0.5) | 4.8f | 4.3–5.1 | 6.9 | 5.6–7.5 | 3.8f | 3.3–4.3 | 3.6f | 2.9–4.0 | 4.3f | 3.2–4.9 | |
| AmB (1.5) | 3.0f,g | 2.7–3.3 | 5.9f | 5.0–6.4 | 2.7f,g | 2.4–2.9 | 2.7f,g | 0.3–3.4 | 3.3f,g | 3.0–3.5 | |
| FLC-AmB (0.5) | 5.0f | 4.1–5.3 | 7.1 | 3.6–7.4 | 4.0f | 3.2–4.5 | 4.0f | 2.6–4.5 | 4.6f | 4.1–5.0 | |
| FLC-AmB (1.5) | 3.3f | 1.4–3.8 | 2.9f,h | 2.8–3.0 | 2.9f | 2.6–3.1 | 2.5f | 0.6–3.0 | 3.2f | 3.0–3.4 | |
↵a See the text for details. There were seven mice in each treatment group.
↵b P < 0.05 , any treatment versus control.
↵c P < 0.05 , FLC versus AmB.
↵d P < 0.05 , sequential therapy versus FLC.
↵e P < 0.05, sequential therapy versus AmB.
↵f P < 0.05 , any treatment versus control.
↵g P < 0.05 , AmB at 1.5 mg/kg/day versus AmB at 0.5 mg/kg/day.
↵h P < 0.05, sequential therapy versus AmB.