Table 1.

Mode of interactions between triazoles and AmB in 15 isolates of C. neoformans

IsolateMIC (μg/ml)AmB-FLC FICMIC (μg/ml)AmB-ITC FICMIC (μg/ml)AmB-SCH FIC
AmBaFLCAmB-FLCITCAmB-ITCSCHAmB-SCH
ATCC 901121.08.00.03/4.00.530.250.5/0.1251.001.00.5/0.0150.51
4860.5/1.0/0.58.00.03/8.01.061.00.06/0.50.561.00.125/0.060.31
4910.25/1.0/0.51.00.125/0.51.000.50.06/0.250.560.1250.25/0.0150.62
4920.5/1.0/0.54.00.03/4.01.061.00.03/1.01.031.00.125/0.50.75
5261.0/1.0/0.58.00.25/2.00.500.50.03/0.250.530.50.125/0.0150.28
10940.5/1.0/0.58.00.25/0.060.510.50.25/0.250.750.50.125/0.250.75
18801.0/0.5/0.52.00.03/1.00.530.250.03/0.251.060.250.03/0.251.06
19930.5/1.0/0.52.00.03/2.01.060.250.5/0.0070.530.50.125/0.030.31
23371.0/0.5/0.54.00.5/0.50.620.250.06/0.251.120.250.03/0.251.06
23411.04.00.25/2.00.750.50.06/0.250.560.50.25/0.1250.50
27151.0/0.5/1.0160.03/8.00.530.50.125/0.250.751.00.25/0.250.50
28531.0/1.0/0.52.00.125/1.00.620.250.5/0.030.620.250.25/0.0150.56
28811.0/1.0/0.58.00.03/4.00.531.00.25/0.250.501.00.25/0.250.75
30590.54.00.03/2.00.560.250.25/0.1251.000.50.25/0.251.00
31231.0/1.0/0.52.00.03/2.01.030.250.03/0.1250.530.1250.25/0.030.74
  • a When only one value (e.g., 1.0 μg/ml) is given, the AmB MIC was always, for example, 1.0 μg/ml for each drug combination; when three values (e.g., 1.0/1.0/0.5 μg/ml) are reported, it means that the AmB MICs were, for example, 1.0, 1.0, and 0.5 μg/ml in the experiments performed with FLC, ITC, and SCH, respectively.