Table 4.

Nucleotide mutations and amino acid substitutions inbla TEM-like genes and new IRT-encoding genes in comparison with bla TEM-1A,bla TEM-1B,bla TEM-1C, andbla TEM-2 genes

StrainblaTEMMutation (substitution) at nucleotide position (amino acid codon)Reference
32141 (−35)162 (−10)175226 (6)317 (39)346 (48)407 (69)436 (78)581 (127)590 (130)604 (134)682 (160)695 (165)697 (165)913 (237)925 (242)929 (244)1020 (275)1022 (276)
1ACCGACC (Gln)AA (Met)CA (Ile)A (Ser)GTT (Trp)G (Trp)CGC (Arg)G (Arg)A (Asn) 36
1BGTTT 18a
1CT 18
2TA (Lys)GTCA 18a
6020421B-likeTGTTT
7140281B-likeTGTTT
8050091B-likeGGTTT
7100201DTT
8011481EGTGTT
6061601FTGTCA
60904684TGTAG (Asp)
61407884TGTAG (Asp)
81102076GTTG (Gly)T
80301379GTTG (Gly)
80100977GTC (Leu)TTA (Ser)
60110581TC (Leu)G (Val)
61402482TG (Val)A (Gln)
80115578TGG (Val)TCC (Arg)AG (Asp)
81314783TGT (Ile)TCT (Cys)AA (Gln)