Table 4.

Selection of the most active compounds found by 3-D database screening

Compound structureRoche no.IC50 (μM) in hematin polymerization assayIC50 (μM) against P. falciparum growth in culture
NF54K1
Embedded ImageRo 06-8463280.0260.3
Ro 06-9075301.160.97
Ro 10-3428<1000.270.21
Ro 10-89951000.140.29
Ro 47-3191 NTa0.460.3
  • a NT, not tested.