Table 2.

Results of tests for inhibition of hematin polymerization

Chemical source of compoundsNo. of compounds in primary screeningNo. (%) of hits in:No. (%) of active single compounds
Primary screeningReassay
Roche cocktails11,887268 (2.3)69 (0.6)38 (0.3)
NCC9716 (16)16 (16)5 (5.2)
SPECS15,76036 (0.2)13 (0.1)
Combinatorial chemistry libraries1,3800
Microbial broths
 Actinomycetes6,00023 (0.4)3 (0.1)0
 Fungi6,32042 (0.7)17 (0.3)10 (0.2)
 Bacteria2,32013 (0.6)4 (0.2)1