Table 2.

Fluoroquinolone growth inhibition of S. pneumoniae strain 7785 and drug-stimulated DNA cleavage efficiencies of DNA gyrase and topoisomerase IV

DrugMIC (μg/ml) for strain 7785CC25 (μM) for DNA breakagea
GyraseTopoisomerase IV
Ciprofloxacin1–2802.5
Gemifloxacin0.0650.1
  • a CC25, concentration of drug that converts 25% of the substrate DNA to the linear form in the presence of gyrase or topoisomerase IV.