Table 1.

Performance evaluation of the method for simultaneous determination of 3TC-TP and ZDV-TP concentrationsa

Drug (no. of experiments)Theoretical concn (pmol)Calculated concn (pmol)Deviation (%)CV (%)
3TC-TP (5)10.010.55.07.6
50.048.0−4.04.5
150.0154.02.78.4
ZDV-TP (5)0.100.1110.05.0
0.500.49−2.07.5
5.004.88−2.57.4
  • a 3TC-TP and ZDV-TP concentrations are expressed in nominal amounts in picomoles. 3TC-TP and ZDV-TP quality control solutions were spiked with PBMCs and analyzed in the same way as the patient's samples.