Table 2.

Antimicrobial susceptibility of S. marcescensisolates and E. coli transformants with SME enzymes

LocationStrainβ-Lactamase(s)MIC (μg/ml) ofa:
IPMMEMATMFOXCAZ
London S. marcescensS6SME-1, AmpC5126412832<0.25
E. coli4913SME-1, TEM-125632>256168
Minnesota S. marcescens 4176SME-1, AmpC512128641282
E. coli4911SME-1, TEM-125632>256328
UCLA S. marcescens 4126SME-2, AmpC5121281281280.5
E. coli4912SME-2, TEM-125664>256328
Boston S. marcescens 4124SME-2, AmpC512128>25664<0.25
E. coli4914SME-2, TEM-125632>2561616
Controls E. colirecipient<0.5<0.5<0.254<0.25
E. colirecipient/pCR2.1TEM-1<0.5<0.5<0.258<0.25
  • a IPM, imipenem; MEM, meropenem; ATM, aztreonam; FOX, cefoxitin; CAZ, ceftazidime.