Table 3.

Frequency of selection of resistant mutants

MIC (μg/ml) for ISP794Selecting drug concn (Factor of MIC)Frequency of mutation
CiprofloxacinPremafloxacinCiprofloxacinPremafloxacin
0.01626.4 × 10−10–4.0 × 10−7
0.03249.1 × 10−10–<1.0 × 10−9
0.0648<9.1 × 10−10–<1.0 × 10−9
0.522.8 × 10−6–1.5 × 10−5
1.043.0 × 10−8–6.1 × 10−8
2.08<4.5 × 10−11–2.8 × 10−9