Table 3.

The impact of mutational frequency at position 2059 in 23S rRNA on MICsa

StrainA2059:G2059bMIC (μg/ml) of compound:Disk diffusion zone diam (mm) for compound:
ERYCLRAZMJOSTYLSPITELLINCLXSTASTBCLXERYSTB
R64:00.020.050.100.100.390.200.0060.390.0525.003.1230.030.522.1
ML12:23.121.564001.566.253.120.0066.250.1050.003.1222.120.619.3
Z101:312.56.25>4002002004000.00612.50.3950.003.1218.214.019.4
Z10-Spir0:4256.25>4002004008000.00612.50.7850.003.1213.8018.4
  • a Fourteen-membered macrolides: erythromycin (ERY) and clarithromycin (CLR); 15-membered macrolide: azithromycin (AZM); 16-membered macrolides: josamycin (JOS), tylosin (TYL), and spiramycin (SPI); ketolide: telithromycin (TEL); lincosamides: lincomycin (LIN) and clindamycin (CLX); streptogramins: streptogramin A (STA) and streptogramin B (STB).

  • b The ratio of the number of 23S rRNA genes harboring adenine at position 2059 to the number of genes harboring guanine there.