Table 3.

Parameter estimates derived from population pharmacokinetic (C 0 and k) and pharmacodynamic (γ and C 50) modeling and a previously published article (a andk 1)a

ParameterEstimate
P 0 1012
a 1.15/day
k 0.036/day
k 1 3.45/day
C 0 1,200 ng/ml (single dose of 25 mg/kg)
C 0 717 ng/ml (single dose of 15 mg/kg)
γ2.50
C 50 665.4 ng/ml [m · 50.43 · (2)1/2.5]b
  • a Article of White (17).

  • b Where m is equal to 10 and EC90 is equal to 50.43 ng/ml.