Table 3.

Parameter estimates derived from population pharmacokinetic (C0 and k) and pharmacodynamic (γ and C50) modeling and a previously published article (a andk1)a

ParameterEstimate
P01012
a1.15/day
k0.036/day
k13.45/day
C01,200 ng/ml (single dose of 25 mg/kg)
C0717 ng/ml (single dose of 15 mg/kg)
γ2.50
C50665.4 ng/ml [m · 50.43 · (2)1/2.5]b
  • a Article of White (17).

  • b Where m is equal to 10 and EC90 is equal to 50.43 ng/ml.